The critical role and functional mechanism of microRNA-146a in doxorubicin-induced apoptosis in breast cancer cells.

Sara TutunchiParisa NourmohammadiRoghayeh TofighSaeedeh AkhavanMina ZareSadra Samavarchi TehraniGhodratollah Panahi

Published in: Nucleosides, nucleotides & nucleic acids (2024)

Considering the role of doxorubicin in inducing apoptosis and increasing the expression of miR-146a, it can be suggested that this miR is involved in inducing apoptosis in BC cells. In addition, miR-146a can be considered a therapeutic candidate.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
oxidative stress
cell proliferation
long non coding rna
cell cycle arrest
long noncoding rna
poor prognosis
signaling pathway
cell death
breast cancer cells
pi k akt
drug delivery
cancer therapy