Diagnosis, Prognostic Factors and Assessment of ALL in Adults: 2023 ELN Recommendations from a European Expert Panel.
Nicola GökbugetNicolas BoisselSabina ChiarettiHerve DombretMichael DoubekAdele K FieldingRobin FoàSebastian GiebelDieter HoelzerMathilde M Hunault-BergerDavid I MarksGiovanni MartinelliOliver Gerhard OttmannAnita W RijneveldPhilippe RousselotJosep-María RiberaRenato BassanPublished in: Blood (2024)
Working groups of the European Leukemia Net (ELN) have published several important consensus guidelines. Acute lymphoblastic leukemia (ALL) has many different clinical and biological subgroups and the knowledge on disease biology and therapeutic options is increasing exponentially. The European Working Group for Adult ALL has therefore summarized the current state of the art and provided comprehensive consensus recommendations for diagnostic approaches, biologic and clinical characterization, prognostic factors and risk stratification as well as definitions of endpoints and outcomes. Aspects of treatment, management of subgroups and specific situations, aftercare and supportive care are covered in a separate publication. The present recommendation intends to provide guidance for the initial management of adult ALL patients and to define principles as a basis for future collaborative research.
Keyphrases
- prognostic factors
- clinical practice
- acute lymphoblastic leukemia
- healthcare
- quality improvement
- palliative care
- acute myeloid leukemia
- end stage renal disease
- chronic kidney disease
- randomized controlled trial
- skeletal muscle
- young adults
- pain management
- systematic review
- newly diagnosed
- health insurance
- combination therapy
- weight loss
- meta analyses
- patient reported outcomes