SPAK inhibitor ZT-1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia.
Mohammad Iqbal H BhuiyanKhadija HabibMd Tipu SultanFenghua ChenIsrat JahanZhongfang WengMd Shamim RahmanRabia IslamLesley M FoleyT Kevin HitchensXianming DengScott W CannaDandan SunGuodong CaoPublished in: CNS neuroscience & therapeutics (2024)
BCAS-induced upregulation of WNK-SPAK-NKCC1 signaling contributes to white matter-reactive astrogliosis, OL death, and memory impairment. Pharmacological inhibition of the SPAK activity has therapeutic potential for alleviating pathogenesis and memory impairment in VCID.