MicroRNA-181a promotes docetaxel resistance in prostate cancer cells.

Cameron M ArmstrongChengfei LiuWei LouAlan P LombardChristopher P EvansAllen C Gao

Published in: The Prostate (2017)

Overexpression of mir-181a in prostate cancer cells contributes to their resistance to docetaxel and cabazitaxel and inhibition of mir-181a expression can restore treatment response. This is due, in part, to modulation of p53 phosphorylation and apoptosis.

Keyphrases

cell proliferation
long non coding rna
poor prognosis
long noncoding rna
oxidative stress
locally advanced
endoplasmic reticulum stress
transcription factor
cell cycle arrest
squamous cell carcinoma
binding protein
protein kinase