Weighted gene co-expression network analysis reveals key biomarkers and immune infiltration characteristics for bronchial epithelial cells from asthmatic patients.
Qianqian LiuXiaoli TangHaipeng XuJie WenYangyang ChenShoubin XuePublished in: Medicine (2024)
C3, PTGIR, CX3CL1, and PTHLH have important clinical diagnostic values and are correlated with infiltration of multiple immune cell types in asthma. These hub genes, B cells memory, and plasma cells may become important biological targets for therapeutic asthma drug screening and drug design.
Keyphrases
- network analysis
- lung function
- chronic obstructive pulmonary disease
- end stage renal disease
- ejection fraction
- genome wide
- induced apoptosis
- newly diagnosed
- poor prognosis
- chronic kidney disease
- allergic rhinitis
- magnetic resonance
- prognostic factors
- emergency department
- copy number
- genome wide identification
- working memory
- patient reported outcomes
- cystic fibrosis
- computed tomography
- dna methylation
- air pollution
- signaling pathway
- binding protein
- cell proliferation
- transcription factor