Boosting the integration of cell membrane-nanomaterial hybrids via dextran-mediated dynamic dispersion system to capture bioactive compounds in natural products.

Efficient integration is a prerequisite for the application of cell membrane-nanomaterial hybrids (CN hybrids) in bioanalysis, however, the poor dispersity of nanomaterials limits the development of this technology. Although the traditional hydrophilic modification method could improve the dispersity of nanomaterials, it would hinder the coating of the cell membrane, thus making it unsuitable for the integration of CN hybrids. Herein, a method has been proposed to improve the integration efficiency of CN hybrids from a different perspective, that is, establishing a dynamic dispersion system to enhance the interfacial interaction between cell membranes and nanomaterials. Specifically, magnetic graphene oxide (MGO) nanosheets were used as the model carrier and HepG2 cells were used as the source for membrane coating. The addition of the macromolecular stabilizer dextran to the integration process enhanced the dispersity of MGO and avoided the resistance to membrane coating caused by surface modification. Intriguingly, MGO in the dynamic dispersion system showed superior membrane coating ability as compared to hydrophilic modification methods, resulting in the more efficient integration of CN hybrids and greater sensitivity in capturing bioactive compounds from natural products. The proposed design principle provides a brand-new perspective for optimizing the behavior of CN hybrids and can improve the effectiveness of CN hybrids in bioanalytical applications.