Defining the challenges and opportunities for using patient-derived models in prostate cancer research.
W Nathaniel BrennenClémentine Le MagnenSofia KarkampounaNicolas AnselminoNathalie BockNicholas ChooAshlee K ClarkIlsa M ColemanRobin DolgosAlison M FergusonDavid L GoodeMarianna Krutihof-de JulioNora M NavonePeter S NelsonEdward O'NeillLaura H PorterWeranja RanasingheTakuro SunadaElizabeth D WilliamsLisa M ButlerEva CoreyWytske M van WeerdenRenea A TaylorGail P RisbridgerMitchell G LawrencePublished in: The Prostate (2024)
There are several opportunities to maximize the impact of patient-derived models on prostate cancer research. We must develop large, diverse and accessible cohorts of models and more sophisticated methods for emulating the intricacy of patient tumors. In this way, we can use the samples that are generously donated by patients to advance the outcomes of patients in the future.