Implementation of an NGS-based sequencing and gene fusion panel for clinical screening of patients with suspected hematologic malignancies.

Michael A LevyStephanie SantosJennifer KerkhofAlan StuartErfan Aref-EshghiFen GuoBen HedleyHenry WongMichael RauhHarriet FeilotterPhilip BerardiLaura SemenukPing YangJoan KnollPeter AinsworthCatherine Meg McLachlinIan Chin-YeeMichael KovacsUday DeotareAlejandro Lazo-LangnerCyrus HsiaMike KeeneyAnargyros XenocostasChristopher HowlettHanxin LinBekim Sadikovic

Published in: European journal of haematology (2019)

Implementation of a tier-1 NGS-based protocol for gene panel screening provides a comprehensive alternative to targeted molecular testing in patients with suspected hematologic malignancies, with increased diagnostic yield, scalability, reproducibility, and cost effectiveness, making it ideally suited for implementation in clinical laboratories.

Keyphrases

primary care
healthcare
quality improvement
genome wide
copy number
randomized controlled trial
single cell
gene expression
dna methylation