Pentylenetetrazole-induced kindling rat model: miR-182 and miR-27b-3p mediated neuroprotective effect of thymoquinone in the hippocampus.
Mukaddes PalaIsmail MeralNilgun Pala AcikgozŞenay Gorucu YilmazElif TaşlidereSema Karaca OkurSeyma AcarFahri AkbasPublished in: Neurological research (2022)
In the PTZ kindling epilepsy model, the expression of these two miRNAs was regulated by TQ and exerted a neuroprotective effect by controlling the activities of target genes.
Keyphrases
- cerebral ischemia
- poor prognosis
- long non coding rna
- cell proliferation
- subarachnoid hemorrhage
- high glucose
- diabetic rats
- brain injury
- blood brain barrier
- genome wide
- long noncoding rna
- endothelial cells
- bioinformatics analysis
- genome wide identification
- dna methylation
- transcription factor
- prefrontal cortex
- temporal lobe epilepsy