Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice.

Yuan DongShuoshuo LiYiming LuXiaoheng LiYajin LiaoZhixin PengYunfeng LiLin HouZengqiang YuanJinbo Cheng

Published in: Journal of neuroinflammation (2020)

Taken together, our data revealed the pivotal role of NLRP3 inflammasome activation in the regulation of fear memory and the development of PTSD and anxiety disorder, providing a novel target for the clinical treatment of such disorders.

Keyphrases

nlrp inflammasome
stress induced
working memory
electronic health record
prefrontal cortex
big data
posttraumatic stress disorder
social support
depressive symptoms
replacement therapy
combination therapy
skeletal muscle
insulin resistance
smoking cessation