Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice.
Yuan DongShuoshuo LiYiming LuXiaoheng LiYajin LiaoZhixin PengYunfeng LiLin HouZengqiang YuanJinbo ChengPublished in: Journal of neuroinflammation (2020)
Taken together, our data revealed the pivotal role of NLRP3 inflammasome activation in the regulation of fear memory and the development of PTSD and anxiety disorder, providing a novel target for the clinical treatment of such disorders.