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Tumor Vessel Normalization via PFKFB3 Inhibition Alleviates Hypoxia and Increases Tumor Necrosis in Rectal Cancer upon Radiotherapy.

Marcus EdelmannShuang FanTiago De OliveiraTina GoldhardtDorothée SartoriusTeona MidelashviliKarly ConradsNiels Benjamin PaulTim BeißbarthJohannes Robert FleischerMoritz Leander BlumeHanibal BohnenbergerNatasa JosipovicArgyris PapantonisMichael LinnebacherLeif Hendrik DrögeMichael GhadimiStefan RiekenLena-Christin Conradi
Published in: Cancer research communications (2024)
Novel therapies to better treat colorectal cancer are necessary to improve patient outcomes. Therefore, in this study, we evaluated the combination of a metabolic inhibitor (3PO) and standard radiotherapy in different experimental settings. We have observed that the addition of 3PO increased radiation effects, ultimately improving tumor cell response to therapy.
Keyphrases
  • locally advanced
  • rectal cancer
  • early stage
  • radiation induced
  • radiation therapy
  • single cell
  • stem cells
  • squamous cell carcinoma
  • cell therapy
  • mouse model
  • mesenchymal stem cells
  • visible light