Functional NK surrogate biomarkers for inflammatory recurrent pregnancy loss and recurrent implantation failure.
Alejandra Comins-BooIgnacio CristóbalMiguel Fernández-ArqueroEdgard Rodríguez de FríasMarta Calvo UrrutiaLydia Pilar SuárezPilar Gasca EscorialMiguel Ángel HerráizSilvia Sánchez-RamónPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2021)
Our preliminary data on this RPL and RIF cohorts suggest a simple diagnostic tool by combining NKp30 and TIGIT on cytNK cells to better identify a subgroup of RPL and RIF patients with a baseline inflammatory profile. A more rigorous selection of these patients through phenotyping peripheral cytNK cells may better define patients that could benefit from an immunomodulatory treatment to prevent further pregnancy losses. The performance of these biomarkers requires further investigation and validation in independent cohorts.
Keyphrases
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- oxidative stress
- prognostic factors
- peritoneal dialysis
- cell cycle arrest
- pulmonary tuberculosis
- randomized controlled trial
- cell death
- mycobacterium tuberculosis
- high throughput
- electronic health record
- deep learning
- open label
- data analysis