Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis.
Xiaolei WangJia SongYue YuanLuge LiIssam H Abu-TahaJordi HeijmanLiang SunShokoufeh DobrevMarkus KamlerLiang XieXander H T WehrensFrank T HorriganDobromir DobrevNa LiPublished in: Circulation research (2023)
This is the first study to demonstrate a role for the FKBP5-deficiency in atrial arrhythmogenesis and to establish FKBP5 as a negative regulator of hypoxia-inducible factor 1α in cardiomyocytes. Our results identify a potential molecular mechanism for the proarrhythmic NCX1 upregulation in chronic AF patients.
Keyphrases
- atrial fibrillation
- end stage renal disease
- ejection fraction
- newly diagnosed
- cell proliferation
- signaling pathway
- chronic kidney disease
- left atrial
- transcription factor
- prognostic factors
- poor prognosis
- heart failure
- peritoneal dialysis
- patient reported outcomes
- human health
- risk assessment
- patient reported
- smoking cessation