Obesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations.
Cæcilie TrierMette HollenstedTheresia M SchnurrMorten Asp Vonsild LundTenna Ruest Haarmark NielsenGao RuiEhm Astrid AnderssonMathilde SvendstrupDorthe Sadowa BilleAnette P GjesingCilius Esmann FonvigChristine Frithioff-BøjsøeMarie Balslev-HarderShi QuanMichael GamborgOluf PedersenLars H ÄngquistJens-Christian HolmTorben HansenPublished in: International journal of obesity (2005) (2020)
Among Danish children and adolescents with overweight or obesity entering a tertiary lifestyle intervention, 2.5% carried damaging or unresolved MC4R mutations. In contrast to noncarriers, carriers of damaging or unresolved MC4R mutations failed to reduce their BMI SDS during obesity treatment, indicating a need for personalized treatment based on the MC4R genotype.