A porcine model of thoracic aortic aneurysms created with a retrievable drug infusion stent graft mirrors human aneurysm pathophysiology.
Dahlia M KenawyJordan F StaffordFoued AmariDrayson CampbellMahmoud Abdel-RasoulJennifer LeightYoungjae ChunBryan W TillmanPublished in: JVS-vascular science (2024)
An RDIS achieves isolated drug delivery while preserving distal perfusion to achieve an endovascular porcine model of thoracic aneurysms without major surgery. This model may have value for surgical training, device testing, and to better understand aneurysm pathogenesis. Most important, although the RDIS was used to simulate aortic pathology, this tool offers intriguing horizons for focused therapeutic drug delivery directly to aneurysms and, more broadly, focused locoregional drug delivery to vessels and vascular beds.
Keyphrases
- drug delivery
- minimally invasive
- coronary artery
- cancer therapy
- aortic valve
- spinal cord
- drug release
- aortic dissection
- pulmonary artery
- endothelial cells
- left ventricular
- low dose
- coronary artery bypass
- inferior vena cava
- computed tomography
- induced pluripotent stem cells
- emergency department
- abdominal aortic aneurysm
- acute coronary syndrome
- pluripotent stem cells
- magnetic resonance
- drug induced
- atrial fibrillation
- pulmonary embolism
- electronic health record