Protective effect of the multitarget compound DPH-4 on human SSAO/VAP-1-expressing hCMEC/D3 cells under oxygen-glucose deprivation conditions: an in vitro experimental model of cerebral ischaemia.
P SunG EstebanT InokuchiJ Marco-ContellesB B WekslerI A RomeroP O CouraudM UnzetaMontse SoléPublished in: British journal of pharmacology (2015)
From these results, we concluded that the multitarget compound DPH-4 might be of therapeutic benefit to delay the onset and/or progression of the neurological pathologies associated with stroke and AD, which appear to be linked.
Keyphrases
- induced apoptosis
- endothelial cells
- cerebral ischemia
- cell cycle arrest
- atrial fibrillation
- subarachnoid hemorrhage
- induced pluripotent stem cells
- pluripotent stem cells
- blood glucose
- signaling pathway
- endoplasmic reticulum stress
- oxidative stress
- cell death
- blood pressure
- type diabetes
- brain injury
- cell proliferation
- weight loss