Canadian Consensus Guidelines for the Diagnosis and Treatment of Autoimmune Encephalitis in Adults.
Christopher HahnAdrian BudhramKatayoun AlikhaniNasser AlOhalyGrayson BeecherGregg BlevinsJohn BrooksRobert CarruthersJacynthe ComtoisJuthaporn CowanPaula de RoblesJulien HébertRonak K KapadiaSarah LapointeAaron MackieWarren MasonBrienne McLaneAlexandra MuccilliIlia PoliakovPenelope SmythKimberly G WilliamsChristopher E UyJennifer A McCombePublished in: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques (2024)
Autoimmune encephalitis is increasingly recognized as a neurologic cause of acute mental status changes with similar prevalence to infectious encephalitis. Despite rising awareness, approaches to diagnosis remain inconsistent and evidence for optimal treatment is limited. The following Canadian guidelines represent a consensus and evidence (where available) based approach to both the diagnosis and treatment of adult patients with autoimmune encephalitis. The guidelines were developed using a modified RAND process and included input from specialists in autoimmune neurology, neuropsychiatry and infectious diseases. These guidelines are targeted at front line clinicians and were created to provide a pragmatic and practical approach to managing such patients in the acute setting.
Keyphrases
- clinical practice
- drug induced
- multiple sclerosis
- infectious diseases
- liver failure
- end stage renal disease
- respiratory failure
- ejection fraction
- newly diagnosed
- chronic kidney disease
- mental health
- peritoneal dialysis
- risk factors
- prognostic factors
- palliative care
- clinical trial
- randomized controlled trial
- drug delivery
- study protocol
- combination therapy
- replacement therapy
- extracorporeal membrane oxygenation