A Systematic Review on Dementia and Translocator Protein (TSPO): When Nuclear Medicine Highlights an Underlying Expression.
Miriam ConteMaria Silvia De FeoFerdinando CoricaJoana GoricaMarko Magdi Abdou SidrakFlaminia De CristofaroLuca FilippiMaria RicciGiuseppe De VincentisViviana FrantellizziPublished in: Biomolecules (2023)
C. An emerging limitation to this however is that neuroinflammation involves all of the brain which inhibits the possibility of detecting a slight inflammation status change in patients. A partial solution to this is using the cerebellum as a reference region and developing higher TSPO affinity tracers. Moreover, it is necessary to consider the presence of distomers and racemic compounds interfering with pharmacological tracers' effects and increasing the noise ratio in images.
Keyphrases
- newly diagnosed
- end stage renal disease
- poor prognosis
- cognitive impairment
- prognostic factors
- pet imaging
- machine learning
- binding protein
- lipopolysaccharide induced
- deep learning
- optical coherence tomography
- air pollution
- resting state
- cerebral ischemia
- convolutional neural network
- functional connectivity
- patient reported outcomes
- multiple sclerosis
- blood brain barrier
- small molecule