Markers of Vitamin B12 Status in Relation to Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Cognitive Performance.

Babak HooshmandFranziska AppoldPatrick FisslerRobert PerneczkyMarkus OttoHayrettin TumaniMiia KivipeltoChristine A F von Arnim

Published in: Annals of neurology (2023)

Markers of vitamin B12 may be independent predictors of CSF biomarkers of AD and cognitive functioning, with MMA showing the most consistent effects. Randomized controlled trials are needed to determine the importance of vitamin B12 supplementation on slowing structural brain changes and cognitive decline. ANN NEUROL 2023.

Keyphrases

cognitive decline
cerebrospinal fluid
mild cognitive impairment
randomized controlled trial
resting state
systematic review
cerebral ischemia
subarachnoid hemorrhage
blood brain barrier
meta analyses