Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia.

Michiel E AdriaensPeggy PrickaertsMichelle Chan-Seng-YueTwan van den BeuckenVivian E H DahlmansLars M EijssenTimothy BeckBradly G WoutersJan Willem VonckenChris T A Evelo

Published in: Epigenetics & chromatin (2016)

In silico-identified epigenetically sustained and dynamic genomic regions were confirmed through ChIP-PCR in vitro, and obtained results are corroborated by published data and current insights regarding epigenetic regulation.

Keyphrases

electronic health record
high throughput
big data
circulating tumor cells
single cell
molecular docking
randomized controlled trial
long noncoding rna
rna seq
machine learning
gene expression
copy number
artificial intelligence