A unified multi-level model approach to assessing patient responsiveness including; return to normal, minimally important differences and minimal clinically important improvement for patient reported outcome measures.
Adrian SayersVikki WyldeErik LenguerrandRachael Gooberman-HillJill DawsonDavid BeardAndrew PriceAshley W BlomPublished in: BMJ open (2017)
MLM improves the estimation of the SD of baseline and change scores by explicitly incorporating measurement error into the model and avoiding regression to the mean when making individual predictions. Using refined definitions of responsiveness may lead to a reduction in misclassification when attempting to predict who does and does not respond to an intervention and clarifies the similarities between existing methods.