Mechanisms of Long Non-Coding RNA in Breast Cancer.
Bianca GiulianiChiara TordonatoFrancesco NicassioPublished in: International journal of molecular sciences (2023)
The landscape of pervasive transcription in eukaryotic genomes has made space for the identification of thousands of transcripts that are difficult to frame in a specific functional category. A new class has been broadly named as long non-coding RNAs (lncRNAs) and shortly defined as transcripts that are longer than 200 nucleotides with no or limited coding potential. So far, about 19,000 lncRNAs genes have been annotated in the human genome (Gencode 41), nearly matching the number of protein-coding genes. A key scientific priority is the functional characterization of lncRNAs, a major challenge in molecular biology that has encouraged many high-throughput efforts. LncRNA studies have been stimulated by the enormous clinical potential that these molecules promise and have been based on the characterization of their expression and functional mechanisms. In this review, we illustrate some of these mechanisms as they have been pictured in the context of breast cancer.
Keyphrases
- long non coding rna
- poor prognosis
- genome wide identification
- genome wide analysis
- high throughput
- genome wide
- bioinformatics analysis
- transcription factor
- network analysis
- endothelial cells
- single cell
- binding protein
- small molecule
- induced pluripotent stem cells
- quality improvement
- dna methylation
- protein protein
- machine learning
- young adults
- deep learning
- case control
- long noncoding rna