Cancer neovasculature-targeted near-infrared photoimmunotherapy (NIR-PIT) for gastric cancer: different mechanisms of phototoxicity compared to cell membrane-targeted NIR-PIT.
Takashi NishimuraMakoto MitsunagaKimihiro ItoHisataka KobayashiMasayuki SarutaPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2019)
We demonstrated a new approach of NIR-PIT utilizing a target on vascular endothelium, such as VEGFR-2, and this treatment might lead to the development of a new therapeutic strategy for human gastric cancer.
Keyphrases
- photodynamic therapy
- drug release
- fluorescence imaging
- fluorescent probe
- cancer therapy
- endothelial cells
- papillary thyroid
- nitric oxide
- drug delivery
- squamous cell
- vascular endothelial growth factor
- induced pluripotent stem cells
- pluripotent stem cells
- young adults
- combination therapy
- childhood cancer
- lymph node metastasis