PI3KCIIα-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in Mice.

Mouin NasrAlexis FayAdrien LupieriNicole MaletAnne DarmonRana ZahreddineAudrey SwiaderAmandine WahartJulien ViaudAnne Nègre-Salvayre Emilio Hirsch Daniel Monteyne David Perez-Morga Nicolas Dupont Patrice Codogno Damien Ramel Etienne Morel Muriel Laffargue Stéphanie Gayral

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

Our data reveal that mechanical forces variability within the arterial system determines EC autophagic response and supports a central role of PI3KCIIα/mTORC1 axis to prevent EC dysfunction in LSS regions.

Keyphrases

cell death
oxidative stress
cardiovascular disease
quality improvement
electronic health record
endoplasmic reticulum stress
high fat diet induced
genome wide
signaling pathway
single cell
big data
gene expression
adipose tissue
type diabetes
metabolic syndrome
artificial intelligence