Cyr61 Promotes Inflammation of a Gouty Arthritis Model in Rats.

Mi ZhouKan Ze Liang HuaLiu LiuLe KuaiMing Zhang Bin Li Yifei Wang Xin Li

Published in: Mediators of inflammation (2020)

Our study has revealed that Cyr61 is an important regulatory factor for the initiation of inflammation in GA. The high expression of Cyr61 protein can induce synovial cells to produce many inflammatory cytokines, such as IL-1β, TNF-α, and IL-6, partly in an NF-κB-dependent manner. Thus, inhibition of Cyr61 could be a new target and strategy for the prevention and treatment of GA.

Keyphrases

oxidative stress
pet ct
induced apoptosis
rheumatoid arthritis
signaling pathway
poor prognosis
cell cycle arrest
binding protein
transcription factor
pi k akt
single cell
cell death
amino acid
immune response
cell proliferation