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Human EGFRvIII chimeric antigen receptor T cells demonstrate favorable safety profile and curative responses in orthotopic glioblastoma.

Rebecca C AbbottMelinda IliopoulosKatherine A WatsonValeria ArcucciMargareta GoHannah E Hughes-ParryPete SmithMelissa J CallRyan S CrossMisty R Jenkins
Published in: Clinical & translational immunology (2023)
This study demonstrates the preclinical functionality of a highly specific CAR targeting EGFRvIII on human cells. This CAR could be an effective treatment for glioblastoma and warrants future clinical investigation.
Keyphrases
  • combination therapy
  • endothelial cells
  • cancer therapy
  • current status
  • rectal cancer
  • stem cells
  • pluripotent stem cells
  • cell therapy
  • bone marrow
  • drug delivery