Bone-like Polymeric Composites with a Combination of Bioactive Glass and Hydroxyapatite: Simultaneous Enhancement of Mechanical Performance and Bioactivity.

An ideal bone substitute requires not only high bioactivity but also sufficient mechanical performance, which is however inaccessible due to the lack of rational structure and composition design. Here, bioactive glass (BG)/hydroxyapatite (HA)/polyethylene (PE) composites with bone-like structure were prepared via a structuring injection molding. The strong and reciprocating shear field offered by the modified injection molding induced plenty of interlocked shish kebabs, mimicking the aligned collagen fibers in the natural bone. Such a bone-like structure enhanced the strength and toughness of the BG/HA/PE composites simultaneously, compensating the mechanical loss caused by the presence of BG. In vitro cell culture assays demonstrated that the combination of BG and HA significantly promoted cell attachment, proliferation, and alkaline phosphatase activity compared to the use of HA alone. It was attributed to upregulated expression of β-catenin stimulated by BG. The mineralization in simulated body fluid revealed that the BG/HA/PE composite exhibited apatite-forming ability stronger than that of the HA/PE counterpart. The integration of excellent mechanical performance and high bioactivity demonstrated the significant potential of the structured BG/HA/PE composites as load-bearing bone substitutes.