Login / Signup

Six-minute walk test as clinical end point in cardiomyopathy clinical trials, including ATTR-CM: a systematic literature review.

Jose N NativiAli YilmazNoel DasguptaRichard MaceyJames CochraneJudith PeatmanCatherine SummersJennifer LuthRonald Zolty
Published in: Journal of comparative effectiveness research (2024)
Aim: The six-minute walk test (6MWT) is a common measure of functional capacity in patients with heart failure (HF). Primary clinical study end points in cardiomyopathy (CM) trials, including transthyretin-mediated amyloidosis with CM (ATTR-CM), are often limited to hospitalization and mortality. Objective: To investigate the relationship between the 6MWT and hospitalization or mortality in CM, including ATTR-CM. Method: A PRISMA-guided systematic literature review was conducted using search terms for CM, 6MWT, hospitalization and mortality. Results: Forty-one studies were identified that reported 6MWT data and hospitalization or mortality data for patients with CM. The data suggest that a greater 6MWT distance is associated with a reduced risk of hospitalization or mortality in CM. Conclusion: The 6MWT is an accepted alternative end point in CM trials, including ATTR-CM.
Keyphrases
  • cardiovascular events
  • clinical trial
  • heart failure
  • risk factors
  • randomized controlled trial
  • type diabetes
  • systematic review
  • cardiovascular disease
  • coronary artery disease
  • open label
  • phase ii
  • placebo controlled