Tumor necrosis factor α, and agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunophenotype of stem cells from human exfoliated deciduous teeth.
Marizia TrevizaniLaís Lopardi LealJoão Vitor Paes RettoreGilson Costa MacedoCaio César de Souza AlvesSandra Bertelli Ribeiro de CastroAntônio Márcio Resende do CarmoSilvioney Augusto da SilvaCarlos Magno da Costa MarandubaFernando de Sá SilvaPublished in: Einstein (Sao Paulo, Brazil) (2023)
Stem cells from human exfoliated deciduous teeth respond to the endocannabinoid system and TNF-α by altering key immune response molecules. Inhibition of endocannabinoid receptors and TNF-α led to an increase in HLA-DR, PD-L1, and PD-L2 levels in stem cells from human exfoliated deciduous teeth. This study shows the interaction between mesenchymal stromal cells and the immune and endocannabinoid systems.