A polymorphism in the haptoglobin, haptoglobin related protein locus is associated with risk of human sleeping sickness within Cameroonian populations.
Elvis OfonHarry NoyesJulius MulindwaHamidou IlboudoMartin SimuunzaVincent Ebo'oFlobert NjiokouMathurin KoffiBruno BuchetonPythagore FogueChristiane Hertz-FowlerAnnette MacLeodGustave Simonull nullPublished in: PLoS neglected tropical diseases (2017)
The haptoglobin related protein HPR and HP are tightly linked and both are duplicated in some people and may lead to higher activity. This increased production could be responsible of the protection associated with rs8062041 even though this SNP is within HP.