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NDRG1 promotes endothelial dysfunction and hypoxia-induced pulmonary hypertension by targeting TAF15.
Chengwei Li
Junzhu Lv
Gulinuer Wumaier
Yu Zhao
Liang Dong
Yuzhen Zeng
Ning Zhu
Xiujuan Zhang
Jing Wang
Jingwen Xia
Shengqing Li
Published in:
Precision clinical medicine (2023)
Taken together, our results indicate that hypoxia-induced upregulation of NDRG1 contributes to endothelial dysfunction through targeting TAF15, which ultimately contributes to the development of hypoxia-induced PH.
Keyphrases
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pulmonary hypertension
pulmonary artery
poor prognosis
cell proliferation
pulmonary arterial hypertension
cancer therapy
signaling pathway
coronary artery