Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis.
Meghan J ChenowethAnnie R PengAndy Z X ZhuLisa Sanderson CoxNicolle L NollenJasjit S AhluwaliaNeal L BenowitzJo KnightWalter SwardfagerRachel Fynvola TyndalePublished in: Addiction (Abingdon, England) (2021)
In African American light smokers with verified early bupropion use, genetically normal CYP2B6 activity appears to be indirectly associated with greater smoking cessation success in a relationship mediated by higher hydroxybupropion concentration. The mediating effect of higher hydroxybupropion concentration on smoking cessation persists beyond the active treatment phase and does not appear to differ by sex.