Effect of Diets, Familial History, and Alternative Therapies on Genomic Instability of Breast Cancer Patients.
Márcia Fernanda Correia Jardim PazAntônio Luiz Gomes JúniorMarcus Vinícius Oliveira Barros de AlencarShams TabrezMuhammad Torequl IslamNasimudeen R JabirMohammad OvesMohammad Zubair AlamMuhammad Nadeem AsgharEunüs S AliKeylla da Conceição MachadoKátia da Conceição MachadoFelipe Cavalcanti Carneiro da SilvaAndré Luiz Pinho SobralJoão Marcelo de Castro E SousaGermano Pinho de MoraesSiddhartha Kumar MishraJuliana da SilvaAna Amélia de Carvalho Melo-CavalcantePublished in: Applied biochemistry and biotechnology (2018)
This study evaluates a correlation between family history, micronutrients intake, and alternative therapies with genetic instability, before and during breast cancer treatment. For this study, a total of 150 women were selected. Among those, 50 women were breast cancer patients on chemotherapy, while 50 breast cancer patients were on radiotherapy, and 50 were healthy females. All the participants signed the informed consent form and answered the public health questionnaire. Samples of buccal epithelial and peripheral blood cells were collected and analyzed through micronucleus and comet assays. The cells were evaluated for apoptosis and DNA damage. Results showed the association of patients' family history with an increase in toxicogenetic damage before and during cancer therapy. On the other hand, patients with late-onset cancer also presented genetic instability before and during therapy, along with those who did not take sufficient vegetables and alternative therapies. A positive correlation was observed between the genetic instability and alternative therapies, while inverse correlation was recorded with the vegetable consumption. Results clearly explain that the nutritional aspects and alternative therapies influence the genetic instability before and during cancer therapies especially in radiotherapy treated patients. Our data could be used for the monitoring therapies and management of breast cancer patients.
Keyphrases
- late onset
- public health
- oxidative stress
- cell cycle arrest
- induced apoptosis
- end stage renal disease
- dna damage
- newly diagnosed
- ejection fraction
- peripheral blood
- genome wide
- cancer therapy
- copy number
- locally advanced
- early onset
- early stage
- prognostic factors
- papillary thyroid
- polycystic ovary syndrome
- squamous cell carcinoma
- drug delivery
- type diabetes
- machine learning
- cross sectional
- deep learning
- mesenchymal stem cells
- patient reported outcomes
- patient reported
- metabolic syndrome
- body mass index
- dna repair
- insulin resistance
- physical activity
- stem cells
- squamous cell
- signaling pathway
- drinking water
- adipose tissue
- weight gain
- cell therapy
- health risk assessment
- chemotherapy induced