Photodynamic therapy combined to cisplatin potentiates cell death responses of cervical cancer cells.
Laura Marise de FreitasRodolfo Bortolozo SerafimJuliana Ferreira de SousaThaís Fernanda MoreiraCláudia Tavares Dos SantosAmanda Martins BavieraValeria ValenteChristiane Pienna SoaresCarla Raquel FontanaPublished in: BMC cancer (2017)
Our results elicit the potential of combined therapy in diminishing the toxicity of antineoplastic drugs. Ultimately, photodynamic therapy mediated by either methylene blue or Photogem as monotherapy or in combination with cisplatin has low mutagenic potential, which supports its safe use in clinical practice for the treatment of cervical cancer.
Keyphrases
- photodynamic therapy
- cell death
- cell cycle arrest
- clinical practice
- fluorescence imaging
- induced apoptosis
- combination therapy
- oxidative stress
- human health
- randomized controlled trial
- stem cells
- open label
- risk assessment
- endoplasmic reticulum stress
- cell proliferation
- cell therapy
- mesenchymal stem cells
- smoking cessation
- double blind