Low-dose pro-resolving mediators temporally reset the resolution response to microbial inflammation.

Charles Nicholas Serhan Nan Chiang Robert Nshimiyimana

Published in: Molecular medicine (Cambridge, Mass.) (2024)

Infections encountered during ongoing inflammation in mice reset the resolution mechanisms of inflammation via SPM clusters. Low-dose SPMs activate innate immune responses and pathways towards the resolution response that can be reprogrammed.

Keyphrases

low dose
immune response
oxidative stress
single molecule
high dose
microbial community
metabolic syndrome
adipose tissue
inflammatory response
wild type