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Concordance between the results of randomized and non-randomized interventional clinical trials assessing the efficacy of drugs for COVID-19: a cross-sectional study.

Daniel ShepshelovichDafna YahavRonen Ben AmiHadar GoldvaserNoam Tau
Published in: The Journal of antimicrobial chemotherapy (2021)
The results of most non-randomized studies reporting survival benefit of potential anti-COVID-19 drugs were not replicated by large RCTs. Regulators and healthcare professionals should exercise caution and resist the pressure to approve and prescribe drugs of unproven efficacy and potential toxicity to optimize patient care and maintain public trust in medical science.
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