Acyl Radicals from Terminal Alkynes: Photoredox-Catalyzed Acylation of Heteroarenes.

Shaista Sultan Masood Ahmad RizviJaswant KumarBhahwal Ali Shah

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2018)

A photoredox-mediated acylation reaction of electron deficient heteroarenes with terminal alkynes is reported. The method relies on oxidative cleavage of phenylacetylenes for generation of acyl radicals as a key enabling feature. The reaction is regioselective with broad substrate scope. Quantum yield investigations support a radical chain mechanism.

Keyphrases

visible light
electron transfer
fatty acid
machine learning
molecular dynamics
deep learning
room temperature
dna binding
transcription factor
wild type