Identifying Aging and Alzheimer Disease-Associated Somatic Variations in Excitatory Neurons From the Human Frontal Cortex.

Meng ZhangGerard A BoulandHenne Holstege Marcel J T Reinders

Published in: Neurology. Genetics (2023)

Our results show that combining scRNA-seq and WGS data can successfully detect putative somatic mutations. The putative somatic mutations detected from ROSMAP data set have provided new insights into the association of AD and aging with brain somatic mutagenesis.

Keyphrases

copy number
functional connectivity
electronic health record
endothelial cells
resting state
big data
crispr cas
genome wide
single cell
mild cognitive impairment
multiple sclerosis
induced pluripotent stem cells
gene expression
artificial intelligence
deep learning
dna methylation
cerebral ischemia