Upregulation of miR-200a and miR-204 in MPP+ -treated differentiated PC12 cells as a model of Parkinson's disease.
Maryam Talepoor ArdakaniMahsa Rostamian DelavarMasoud BaghiMohammad Hossein Nasr-EsfahaniAbbas Kiani-EsfahaniKamran GhaediPublished in: Molecular genetics & genomic medicine (2019)
The first novel finding of the current study is altered expression of miR-200a and miR-204 in differentiated PC12 cells in response to MPP+ , suggesting that deregulation of them participate in MPP+ neurotoxicity mechanisms, possibly via affecting the expression of Sirt1 and BCL2 as potential targets.