Development and assessment of analytic methods to improve the measurement of cognition in longitudinal studies of aging through the use of substudies with comprehensive neuropsychological testing.

Emma NicholsRichard N JonesAlden L GrossShabina HayatPaola ZaninottoJinkook Lee

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Estimates of cognitive functioning informed by English Longitudinal Study of Ageing-Harmonized Cognitive Assessment Protocol (ELSA-HCAP) data had an adequate performance. Standard errors were smaller for associations with example risks when using measures informed by ELSA-HCAP. Performance was better when including additional cognitive measures available in waves 7 to 9. Conceptual advantages to the confirmatory factor analysis (CFA) approach were not important in practice due to the brevity of the ELSA cognitive battery.

Keyphrases

randomized controlled trial
healthcare
mild cognitive impairment
primary care
emergency department
electronic health record
risk assessment
multiple sclerosis
white matter
deep learning
human health
adverse drug