Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease.
Ellen H SingletonOskar HanssonYolande A L PijnenburgRenaud La JoieWilliam G MantyhPontus TidemanErik StomrudAntoine LeuzyMaurits JohanssonOlof StrandbergRuben SmithEvi BerendrechtBruce L MillerLeonardo IaccarinoLauren EdwardsAmelia StromEmma E WoltersEmma CoomansDenise VisserSandeep S V GollaHayel TuncelFemke BouwmanJohn Cornelis van SwietenJanne M PapmaBart van BerckelPhilip ScheltensYolande A L PijnenburgGil D RabinoviciRik OssenkoppelePublished in: Journal of neurology, neurosurgery, and psychiatry (2021)
Both in-vivo and ex-vivo, patients with bvAD showed heterogeneous distributions of tau pathology. Since key regions involved in behavioural regulation were not consistently disproportionally affected by tau pathology, other factors are more likely driving the clinical phenotype in bvAD.
Keyphrases