Peptides for microbe-induced cancers: latest therapeutic strategies and their advanced technologies.
Ziqi LinYehuda G AssarafHang Fai KwokPublished in: Cancer metastasis reviews (2024)
Cancer is a significant global health concern associated with multiple distinct factors, including microbial and viral infections. Numerous studies have elucidated the role of microorganisms, such as Helicobacter pylori (H. pylori), as well as viruses for example human papillomavirus (HPV), hepatitis B virus (HBV), and hepatitis C virus (HCV), in the development of human malignancies. Substantial attention has been focused on the treatment of these microorganism- and virus-associated cancers, with promising outcomes observed in studies employing peptide-based therapies. The current paper provides an overview of microbe- and virus-induced cancers and their underlying molecular mechanisms. We discuss an assortment of peptide-based therapies which are currently being developed, including tumor-targeting peptides and microbial/viral peptide-based vaccines. We describe the major technological advancements that have been made in the design, screening, and delivery of peptides as anticancer agents. The primary focus of the current review is to provide insight into the latest research and development in this field and to provide a realistic glimpse into the future of peptide-based therapies for microbe- and virus-induced neoplasms.
Keyphrases
- hepatitis b virus
- helicobacter pylori
- hepatitis c virus
- high glucose
- diabetic rats
- global health
- endothelial cells
- microbial community
- drug induced
- public health
- helicobacter pylori infection
- oxidative stress
- squamous cell carcinoma
- metabolic syndrome
- weight loss
- glycemic control
- stress induced
- antiretroviral therapy