Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes.
Chunwan LuJohn D KlementMohammed L IbrahimWei XiaoPriscilla S ReddAsha Nayak-KapoorGang ZhouZhuoqi LiuPublished in: Journal for immunotherapy of cancer (2019)
IFN-I induces STAT3 activation to activate Gzmb expression to enhance CTL effector function to suppress tumor development. Human colorectal carcinoma may use down-regulation of IFNAR1 on CTLs to suppress CTL effector function to evade host cancer immunosurveillance.