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Serum IgG4 Subclass Deficiency Defines a Distinct, Commonly Encountered, Severe Inflammatory Bowel Disease Subtype.

Filippos KoutroumpakisAnna Evans PhillipsDhiraj YadavJorge D MachicadoMaaz AhsanClaudia Ramos RiversXiaoqing TanMarc SchwartzSiobhan ProksellElyse JohnstonJeffrey DuekerJana G HashashArthur BarrieJanet HarrisonMichael A DunnLiza KonnikovaDouglas J HartmanHasieb DinDmitriy BabichenkoGong TangDavid G Binion
Published in: Inflammatory bowel diseases (2022)
An IgG4 subclass deficiency, distinct from other antibody deficiencies, occurred commonly in a referral IBD population and was associated with multiple markers of disease severity. This is the first association of IgG4 subclass deficiency with an inflammatory disease process. Further work is needed to define the mechanistic role of IgG4 deficiency in this severe IBD subgroup.
Keyphrases
  • replacement therapy
  • early onset
  • primary care
  • ulcerative colitis
  • oxidative stress
  • randomized controlled trial
  • drug induced
  • open label
  • study protocol