Autophagy and Inflammasome Activation in Dilated Cardiomyopathy.

Angela CaragnanoAneta AleksovaMichela BulfoniCeleste CervellinIrene Giulia RolleClaudia VenezianoArianna BarchiesiMaria Chiara MimmiCarlo VascottoNicoletta FinatoSandro SpongaUgolino LiviMiriam IsolaCarla Di LoretoRossana BussaniGianfranco SinagraDaniela Cesselli Antonio Paolo Beltrami

Published in: Journal of clinical medicine (2019)

We identified, in human DCM, a complex series of events whose key players are miR-22, PP2Cm, BCAA, mTOR, and ALP, linking loss of proteostasis with inflammasome activation. These potential therapeutic targets deserve to be further investigated.

Keyphrases

cell proliferation
endothelial cells
long non coding rna
cell death
oxidative stress
signaling pathway
endoplasmic reticulum stress
pluripotent stem cells
atomic force microscopy
high resolution
mass spectrometry
risk assessment
climate change
high speed