Intrinsic cholinergic innervation in the human sigmoid colon revealed using CLARITY, three-dimensional (3D) imaging, and a novel anti-human peripheral choline acetyltransferase (hpChAT) antiserum.
Pu-Qing YuanJean-Pierre BellierTao LiMary R KwaanHiroshi KimuraYvette TachéPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
The intrinsic cholinergic innervation in the human sigmoid colon was demonstrated layer by layer for the first time in 3D microstructures. This may open a new venue to assess the structure-function relationships and pathological alterations in colonic diseases.