Muscle Expression of Type I and Type II Interferons Is Increased in Juvenile Dermatomyositis and Related to Clinical and Histologic Features.
Gian Marco MonetaDenise Pires MarafonEmiliano MarascoSilvia RosinaMargherita VerardoChiara FiorilloCarlo MinettiLuisa Bracci-LaudieroAngelo RavelliFabrizio De BenedettiRebecca NicolaiPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
The increased expression of IFN-inducible genes in the muscle in juvenile DM patients and their association with histologic and clinical features further support a pathogenic role for both type I and type II IFNs in juvenile DM.
Keyphrases
- poor prognosis
- end stage renal disease
- skeletal muscle
- ejection fraction
- immune response
- prognostic factors
- peritoneal dialysis
- dendritic cells
- metabolic syndrome
- long non coding rna
- patient reported outcomes
- gene expression
- glycemic control
- dna methylation
- rheumatoid arthritis
- systemic lupus erythematosus
- disease activity
- patient reported
- transcription factor
- genome wide identification