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Robust, scalable construction of an electrophilic deuterated methylthiolating reagent: facile access to SCD 3 -containing scaffolds.

Xiao XiaoYin-Qiu HuangHong-Yu TianJun BaiFei ChengXu WangMiao-Lin KeXiangtao Chen
Published in: Chemical communications (Cambridge, England) (2022)
We have established a practical and concise method for the straightforward access of a universal deuterated methylthiolating reagent through a one-pot gram-scale operation under mild conditions. This odourless electrophilic SCD 3 reagent was widely applied to react with numerous representative nucleophiles and approached various valuable SCD 3 analogues with excellent levels of deuterium content (>99% D). The divergent further transformations were smoothly carried out to obtain the significant derivatives with different oxidative states in high efficiency.
Keyphrases
  • high efficiency
  • gram negative
  • structure activity relationship
  • cross sectional
  • molecular docking
  • quantum dots
  • multidrug resistant
  • gold nanoparticles
  • metal organic framework