Advancements in Protein Degradation for Cancer Therapy.

The continuous pursuit of novel therapeutic approaches to modulate biological processes and combat diseases such as cancer has led to significant advancements in protein degradation. This Patent Highlight reviews three recent patents introducing innovative compositions and methods to enhance enzyme activity and target protein degradation. These patents present groundbreaking advancements in the development of glutarimide-containing compounds and Protein-Protein Interaction Targeted Chimeras (PPI-TACs) aimed at improving therapeutic interventions' efficacy, selectivity, and stability.