Patterns of Adherence to a Dapivirine Vaginal Ring for HIV-1 Prevention Among South African Women in a Phase III Randomized Controlled Trial.
Erica N BrowneElizabeth R BrownThesla Palanee-PhillipsKrishnaveni ReddyLogashvari NaidooNitesha JeenarainGonasagrie NairMarla J HusnikDevika SinghRachel ScheckterLydia Soto-TorresJared M BaetenAriane van der Stratennull nullPublished in: Journal of acquired immune deficiency syndromes (1999) (2022)
Most South African women successfully persisted with a moderate or high level of use. Encouraging ring replacement with completion of menses may help to decrease concerns about hygiene and improve persistence. Associations between contraception and persistent low adherence suggest efforts may be needed to ensure contraceptive method choice does not interfere with ring use.